PFAS Linked to Gut Health Issues in Young Adults, New Study Finds

By: The Guardian

Nov 5, 2024

A recent study has linked exposure to toxic PFAS "forever chemicals" in young adults to reduced gut health, which may contribute to kidney disease later in life. Researchers from the University of Southern California found that changes in gut bacteria and associated metabolites caused by PFAS accounted for up to 50% of the decrease in kidney function observed over four years. Kidney disease, already associated with PFAS exposure, is a growing public health concern in the U.S., especially as it is closely tied to metabolic diseases such as diabetes.

PFAS are synthetic chemicals used in products to enhance water, stain, and grease resistance. Known for their persistence in the environment, they are associated with severe health issues, including cancer, immune dysfunction, and kidney disease. Building on evidence that PFAS affect gut health, the researchers studied a small cohort of young adults, primarily Hispanic, to investigate the connection between gut health and kidney function. By analyzing blood and stool samples, they found reduced anti-inflammatory metabolites and increased inflammatory ones, which corresponded to decreased kidney function over time.

While the study highlights potential avenues for preventing or treating kidney disease linked to PFAS exposure, such as dietary interventions and new drug treatments, its authors emphasize the importance of addressing the source of the problem. Reducing PFAS production and limiting environmental and consumer exposure are critical steps, according to co-author Hailey Hampson. The findings also underscore the need for broader research to further explore the link between PFAS, gut health, and kidney disease.

For more details, see the original article and the published study.